Sabuncu MR, Shenton ME, Golland P
Med Image Comput Comput Assist Interv 2007;10(WS):47-54
We demonstrate an EM-based algorithm that jointly registers and clusters a group of images using an affine transformation model. The output is a small number of prototype images that represent the different modes of the population. The proposed algorithm can be viewed as a generalization of other well-known atlas construction algorithms, where the collection of prototypes represent multiple atlases for that population. Our experiments indicate that the employment of multiple atlases improves the localization of the underlying structure in a new subject.