Free-Form B-spline Deformation Model for Groupwise Registration

Balci SK, Golland P, Shenton M, Wells WM

Med Image Comput Comput Assist Interv 2007;10(WS):23-30

PMID: 20224762


In this work, we extend a previously demonstrated entropy based groupwise registration method to include a free-form deformation model based on B-splines. We provide an efficient implementation using stochastic gradient descents in a multi-resolution setting. We demonstrate the method in application to a set of 50 MRI brain scans and compare the results to a pairwise approach using segmentation labels to evaluate the quality of alignment. Our results indicate that increasing the complexity of the deformation model improves registration accuracy significantly, especially at cortical regions.