Savadjiev P, Campbell JS, Pike GB, Siddiqi K
Med Image Comput Comput Assist Interv 2005;8(Pt 1):123-30
We develop a differential geometric framework for regularizing diffusion MRI data. The key idea is to model white matter fibers as 3D space curves and to then extend Parent and Zucker’s 2D curve inference approach  by using a notion of co-helicity to indicate compatibility between fibre orientation estimates at each voxel with those in a local neighborhood. We argue that this provides several advantages over earlier regularization methods. We validate the approach quantitatively on a biological phantom and on synthetic data, and qualitatively on data acquired in vivo from a human brain.