Joint generative model for fMRI/DWI and its application to population studies

Venkataraman A, Rathi Y, Kubicki M, Westin CF, Golland P

Med Image Comput Comput Assist Interv 2010;13(Pt 1):191-9

PMID: 20879231


We propose a novel probabilistic framework to merge information from DWI tractography and resting-state fMRI correlations. In particular, we model the interaction of latent anatomical and functional connectivity templates between brain regions and present an intuitive extension to population studies. We employ a mean-field approximation to fit the new model to the data. The resulting algorithm identifies differences in latent connectivity between the groups. We demonstrate our method on a study of normal controls and schizophrenia patients.