Oribe N, Hirano Y, Kanba S, del Re EC, Seidman LJ, Mesholam-Gately R, Spencer KM, McCarley RW, Niznikiewicz MA
Schizophr. Res. 2013 May;146(1-3):95-102
BACKGROUND: P300 deficits in schizophrenia patients are well established, especially in the auditory modality. Several studies have also reported P300 abnormalities in schizophrenia in visual tasks, but these findings are inconsistent. Furthermore, reports on P300 in visual modality in prodromal subjects are very limited. While P300 indexes relatively late and complex cognitive functions such as context updating in working memory, sensory-evoked components such as the P1/N1 primarily index early stages of perceptual processing. Several previous studies suggest that P300 reduction in schizophrenia patients may be dissociable from these earlier components. Therefore, in this study, we measured the P300 component as well as the P1/N1 in a visual oddball paradigm in prodromal subjects and first episode schizophrenia patients, and compared them with those of healthy controls.
METHOD: Visual P300 and P1/N1 were obtained from prodromal (PRO, n = 23), first episode schizophrenia patients (SZ, n = 17), and healthy control subjects (HC, n = 31), who silently counted infrequent target stimuli (“X”) amid standard stimuli (“Y”) presented on the screen while 64-channel EEG was recorded.
RESULTS: Both PRO and SZ subjects showed reduced P300 amplitudes and delayed P300 peak latencies in comparison to control subjects. On the other hand, N1 amplitude was significantly reduced only in SZ but not in PRO. Increased severity of positive symptoms was significantly associated with smaller P300 amplitude in PRO.
CONCLUSIONS: These results suggest that visual P300 is affected already at the prodromal stage and could be a marker of the prodromal phase of schizophrenia.