Correlations between abnormal auditory P300 topography and positive symptoms in schizophrenia: a preliminary report

Shenton ME, Faux SF, McCarley RW, Ballinger R, Coleman M, Torello M, Duffy FH

Biol. Psychiatry 1989 Mar;25(6):710-6

PMID: 2923933


P300 component amplitude in the left temporal scalp region, shown in three previous studies to differentiate normals from schizophrenics, was found to be significantly correlated with the Thought Disorder Index (TDI) and the Scale for the Assessment of Positive Symptoms (SAPS). These correlations occurred primarily in the P300 waveform derived from the Goodin paradigm. These findings suggest a brain processing disturbance in positive symptom schizophrenia that may be reflected by electrophysiological abnormalities detectable in the temporal scalp region.