McCarthy-Jones S, Oestreich LKL, Lyall AE, Kikinis Z, Newell DT, Savadjiev P, Shenton ME, Kubicki M, Pasternak O, Whitford TJ, Brain Imaging Behav 2018 Apr;12(2):449-458 PMID: 28341872 Abstract Diffusion tensor imaging studies report childhood adversity (CA) is associated with reduced fractional anisotropy (FA) in multiple white matter tracts in adults.… read more →
Oestreich LKL, Lyall AE, Pasternak O, Kikinis Z, Newell DT, Savadjiev P, Bouix S, Shenton ME, Kubicki M, , Whitford TJ, McCarthy-Jones S Schizophr. Res. 2017 11;189:153-161 PMID: 28190639 Abstract Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but often inconsistent patterns of white matter abnormalities. These… read more →
Oestreich LK, Pasternak O, Shenton ME, Kubicki M, Gong X, , McCarthy-Jones S, Whitford TJ Neuroimage Clin 2016;12:405-14 PMID: 27622137 Abstract BACKGROUND: There is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major fasciculi… read more →
Bergamino M, Pasternak O, Farmer M, Shenton ME, Hamilton JP Neuroimage Clin 2016;10:336-42 PMID: 27006903 Abstract Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted development of this literature. Effects of… read more →
Pasternak O, Shenton ME, Westin CF Med Image Comput Comput Assist Interv 2012;15(Pt 2):305-12 PMID: 23286062 Abstract Diffusion MRI measures micron scale displacement of water molecules, providing unique insight into microstructural tissue architecture. However, current practical image resolution is in the millimeter scale, and thus diffusivities from many tissue compartments… read more →
Pasternak O, Westin CF, Bouix S, Seidman LJ, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, McCarley RW, Kikinis R, Shenton ME, Kubicki M J. Neurosci. 2012 Nov;32(48):17365-72 PMID: 23197727 Abstract Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the… read more →
Pasternak O, Sochen N, Gur Y, Intrator N, Assaf Y Magn Reson Med 2009 Sep;62(3):717-30 PMID: 19623619 Abstract Relating brain tissue properties to diffusion tensor imaging (DTI) is limited when an image voxel contains partial volume of brain tissue with free water, such as cerebrospinal fluid or edema, rendering the… read more →
Ofori E, Pasternak O, Planetta PJ, Burciu R, Snyder A, Febo M, Golde TE, Okun MS, Vaillancourt DE Neurobiol. Aging 2015 Feb;36(2):1097-104 PMID: 25467638 Abstract Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson’s disease. It is the case, however, that partial volume effects from… read more →
Mandl RC, Pasternak O, Cahn W, Kubicki M, Kahn RS, Shenton ME, Hulshoff Pol HE Schizophr. Res. 2015 Jan;161(1):126-32 PMID: 25454797 Abstract Diffusion weighted imaging (DWI) has been extensively used to study the microarchitecture of white matter in schizophrenia. However, popular DWI-derived measures such as fractional anisotropy (FA) may be… read more →
Pasternak O, Westin CF, Dahlben B, Bouix S, Kubicki M Schizophr. Res. 2015 Jan;161(1):113-8 PMID: 25126717 Abstract In a previous study we have demonstrated, using a novel diffusion MRI analysis called free-water imaging, that the early stages of schizophrenia are more likely associated with a neuroinflammatory response and less so… read more →
