Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome

Takeoka M, Riviello JJ, Duffy FH, Kim F, Kennedy DN, Makris N, Caviness VS, Holmes GL

Neurology 2004 Oct;63(7):1289-92

PMID: 15477555


No specific anatomic abnormalities have been detected in typical Landau-Kleffner syndrome (LKS), an acquired epileptic aphasia with language regression in children. In four children with typical LKS without obvious anatomic abnormalities, the authors performed MRI volumetric analysis of various neocortical regions and subcortical substructures. Volume reduction was detected in bilateral superior temporal areas (26 to 51%), specifically in planum temporale (25 to 63%) and superior temporal gyrus (25 to 57%), where receptive language is localized.