Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study

Makris N, Seidman LJ, Valera EM, Biederman J, Monuteaux MC, Kennedy DN, Caviness VS, Bush G, Crum K, Brown AB, Faraone SV

J Atten Disord 2010 Jan;13(4):407-13

PMID: 20008822


OBJECTIVE: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD.

METHOD: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naïve adults with ADHD (n = 13).

RESULTS: There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group.

CONCLUSION: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment.