A new generation of MR imaging techniques has made it possible to quantify the volume of both whole brain and small brain structures with an enhanced precision, thus allowing a more accurate and detailed assessment of structural brain anomalies in schizophrenia. Our original study (Shenton et al., 1992, see below),… read more →

Our group began research in 2008 in the area of traumatic brain injury (TBI) when we began our collaboration with Dr. Ross Zafonte, Director of the Spaulding Rehabilitation Center. Dr. Zafonte is also principal investigator of the Harvard Clinical Defense Consortium Site on post-traumatic stress disorder (PTSD) and TBI, along with Drs.… read more →

Magnetic resonance imaging (MRI) has been useful in revealing subtle structural brain abnormalities in schizophrenia patients, including ventricular enlargement, volume reduction in the frontal and parietal lobes, and gray matter reduction of medial temporal lobe structures (see Shenton et al., 2001 for a review of abnormal MRI findings in schizophrenia; see also McCarley… read more →

Recently there has been an increased interest in studying the neurobiology of personality disorders, and, in particular, schizotypal personality disorder (SPD). SPD is characterised by cognitive or perceptual distortions, an inability to tolerate close friendships, and odd behavior, but not frank psychosis. Of particular importance to SPD is the concept… read more →