Mismatch negativity and first episode schizophrenia

D. F. Salisbury, M. E. Shenton, C. B. Griggs, A. Bonner-Jackson, R. W. McCarley
Arch Gen Psychiatry
Volume 59, Pages 686-694

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Background: Mismatch negativity (MMN) is an event-related brain potential that is sensitive to stimulus deviation from a repetitive pattern. The MMN is thought primarily to reflect the activity of sensory memory, with, at most, moderate influences of higher-level cognitive processes, such as attention. The MMN is reported to be reduced in patients with chronic schizophrenia. However, it is unknown whether MMN is reduced in patients with first-episode schizophrenia (at first hospitalization).

Methods: Subject groups comprised patients with chronic schizophrenia (n = 16) and older control subjects (n = 13), and patients with first-episode schizophrenia (n = 21) and younger control subjects (n = 27). The MMN was visualized by subtracting the averaged event-related brain potential to standard tones (1 kHz [95 tones]) from the event-related brain potential to pitch-deviant tones (1.2 kHz [5 100 to 200 milliseconds.

Results: Pitch-deviant MMN was reduced by approximately 47 in patients with chronic illness along the sagittal midline relative to controls. The MMN was not reduced in patients with first-episode schizophrenia. All 4 groups showed approximately 64 pitch-deviant tones over the right hemisphere compared with the left hemisphere.

Conclusions: The pitch-deviant MMN reductions present in patients with chronic schizophrenia are not present at first hospitalization. The sensory, echoic memory functions indexed by MMN seem unaffected early in the schizophrenia disease process. Reductions in MMN amplitude may develop over time and index the progression of the disorder, although that can only be definitively determined by longitudinal assessments.


Salisbury DF, Shenton ME, Griggs CB, Bonner-Jackson A, McCarley RW. Mismatch negativity and first episode schizophrenia. Arch Gen Psychiatry 2002;59:686-694.


VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009, VA Schizophrenia Center Grant, NIH RO1 MH40977, NIH/NIMH 2K02 MH01110, NIH RO1 MH50747, Young Investigator NARSAD (DFS)

Research areas

chronic, fe
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