Reduced left angular gyrus volume in first-episode schizophrenia

J. Nierenberg, D. F. Salisbury, J. J. Levitt, E. A. David, R. W. McCarley, M. E. Shenton
Am J Psychiatry
Volume 162, Pages 1539-1541

Download full paper


Objective: Research suggests that the normal left-greater-than-right angular gyrus volume asymmetry is reversed in chronic schizophrenia. The authors examined whether angular gyrus volume and asymmetry were abnormal in patients with first-episode schizophrenia.

Method: Magnetic resonance imaging scans were obtained from 14 inpatients at their first hospitalization for psychosis and 14 normal comparison subjects. Manual editing was undertaken to delineate postcentral, supramarginal, and angular gyri gray matter volumes.

Results: Group comparisons revealed that the left angular gyrus gray matter volume in patients was 14.8 normal subjects. None of the other regions measured showed significant group volume or asymmetry differences.

Conclusions: Patients with new-onset schizophrenia showed smaller left angular gyrus volumes than normal subjects, consistent with other studies showing parietal lobe volume abnormalities in schizophrenia. Angular gyrus pathology in first-episode patients suggests that the angular gyrus may be a neuroanatomical substrate for the expression of schizophrenia.


Nierenberg J, Salisbury DF, Levitt JJ, David EA, McCarley RW, Shenton ME. Reduced left angular gyrus volume in first-episode schizophrenia. Am J Psychiatry 2005;162:1539-1541.


Dupont-Warren, VA Merit Award, REAP, MIND Foundation, NIH/NIMH 2R01 MH01110, NIH RO1 MH50747,

Research area

© 2013 Psychiatry Neuroimaging Laboratory | Last updated 04.15.2013