Neuropsychological correlates of diffusion tensor imaging in schizophrenia

P. G. Nestor, M. Kubicki, R. J. Gurrera, M. Niznikiewicz, M. Frumin, R. W. McCarley, M. E. Shenton
Volume 18, Number 4, Pages 629-637

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Patients with schizophrenia (n = 41) and healthy comparison participants (n = 46) completed neuropsychological measures of intelligence, memory, and executive function. A subset of each group also completed magnetic resonance diffusion tensor imaging (DTI) studies (fractional anisotropy and cross-sectional area) of the uncinate fasciculus (UF) and cingulate bundle (CB). Patients with schizophrenia showed reduced levels of functioning across all neuropsychological measures. In addition, selective neuropsychological-DTI relationships emerged. Among patients but not controls, lower levels of declarative-episodic verbal memory correlated with reduced left UF, whereas executive function errors related to performance monitoring correlated with reduced left CB. The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia.


Nestor PG, Kubicki M, Gurrera RJ, Niznikiewicz M, Frumin M, McCarley RW, Shenton ME. Neuropsychological correlates of diffusion tensor imaging in schizophrenia. Neuropsychology 2004;18(4):629-637.


Young Investigator NARSAD(Nestor), Kosciuszko Foundation Research Award, NIH/NIMH 2KO2 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799, VA Merit Award(MES)2000-2008, VA Psychiatry/Neuroscience Research Fellowship

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