Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia

R. W. McCarley, D. F. Salisbury, Y. Hirayasu, D. A. Yurgelun-Todd, M. Tohen, C. Zarate, R. Kikinis, F. A. Jolesz, M. E. Shenton
Arch Gen Psychiatry
Volume 59, Pages 321-331
2002

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Abstract

Background: In chronic schizophrenia, the P300 is broadly reduced and shows a localized left temporal deficit specifically associated with reduced gray matter volume of the left posterior superior temporal gyrus (STG). In first-episode patients, a similar left temporal P300 deficit is present in schizophrenia, but not in affective psychosis. The present study investigated whether the left temporal P300-left posterior STG volume association is selectively present in first-episode schizophrenia.

Method: P300 was recorded as first-episode subjects with schizophrenia (n = 15) or affective psychosis (n = 18) or control subjects (n = 18) silently counted infrequent target tones amid standard tones. High-resolution spoiled gradient-recalled acquisition magnetic resonance images provided quantitative measures of temporal lobe gray matter regions of interest.

Results: Patients with first-episode schizophrenia displayed a reversed P300 temporal area asymmetry (smaller on the left), while magnetic resonance imaging showed smaller gray matter volumes of left posterior STG relative to control subjects and patients with affective psychosis (15.4 of left planum temporale (21.0 Heschl's gyrus volume (14.6 STG and the left planum temporale, but not other regions of interest, were specifically and positively correlated (r>0.5) with left temporal P300 voltage in patients with schizophrenia but not in patients with affective psychosis or in control subjects.

Conclusion: These results suggest that the left temporal P300 abnormality specifically associated with left posterior STG gray matter volume reduction is present at the first hospitalization for schizophrenia but is not present at the first hospitalization for affective psychosis.


Reference

McCarley RW, Salisbury DF, Hirayasu Y, Yurgelun-Todd DA, Tohen M, Zarate C, Kikinis R, Jolesz FA, Shenton ME. Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal p300 amplitude in first-episode schizophrenia. Arch Gen Psychiatry 2002;59:321-331.

Grants

VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009, NIH/NIMH 2RO1 MH40799, NIH/NIMH 2K02 MH01110, NIH/NIMH 2RO1 MH50740, Young Investigator NARSAD (DFS)

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