Cavum septum pellucidum in monozygotic twins disordant for combat exposure: Relationship to posttraumatic stress disorder

F. S. May, C. Q. Chen, M. W. Gilbertson, M. E. Shenton, R. K. Pitman
Biol Psychiatry
Volume 55, Number 6, Pages 656-658
2004

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Abstract

Background: Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain.

Methods: We utilized magnetic resonance imaging to measure cavum septum pellucidum in pairs of identical twins discordant for combat exposure in Vietnam.

Results: Presence of abnormal cavum septum pellucidum was significantly correlated between exposed and unexposed twins, indicating that it is partially determined by heredity and/or shared environment. There was a greater proportion of cavum septum pellucidum in combat-exposed twins with posttraumatic stress disorder and their noncombat-exposed co-twins.

Conclusions: The presence of abnormally large cavum septum pellucidum is a familial vulnerability factor for posttraumatic stress disorder.


Reference

May FS, Chen CQ, Gilbertson MW, Shenton ME, Pitman RK. Cavum septum pellucidum in monozygotic twins disordant for combat exposure: Relationship to posttraumatic stress disorder. Biol Psychiatry 2004;55(6):656-658.

Grants

VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009, Middleton Award, Welfide Foundation, Uehara Memorial Foundation, NIH/NIMH 2K02 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799, NIH R01 RR11747, NIH P41 RR13218

Research area

ptsd
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