Cavum septum pellucidum in monozygotic twins disordant for combat exposure: Relationship to posttraumatic stress disorderF. S. May, C. Q. Chen, M. W. Gilbertson, M. E. Shenton, R. K. Pitman
Volume 55, Number 6, Pages 656-658
Background: Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain.
Methods: We utilized magnetic resonance imaging to measure cavum septum pellucidum in pairs of identical twins discordant for combat exposure in Vietnam.
Results: Presence of abnormal cavum septum pellucidum was significantly correlated between exposed and unexposed twins, indicating that it is partially determined by heredity and/or shared environment. There was a greater proportion of cavum septum pellucidum in combat-exposed twins with posttraumatic stress disorder and their noncombat-exposed co-twins.
Conclusions: The presence of abnormally large cavum septum pellucidum is a familial vulnerability factor for posttraumatic stress disorder.