Fusiform gyrus volume reduction in first-episode schizophrenia: A magnetic resonance imaging study

C. U. Lee, M. E. Shenton, D. F. Salisbury, K. Kasai, T. Onitsuka, C. C. Dickey, D. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, R. W. McCarley
Arch Gen Psychiatry
Volume 59, Pages 775-781

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Background: The fusiform gyrus (occipitotemporal gyrus) is thought to be critical for face recognition and may possibly be associated with impaired facial recognition and interpretation of facial expression in schizophrenia. of postmortem studies have suggested that fusiform gyrus volume is reduced in schizophrenia, but there have been no in vivo structural studies of the fusiform gyrus in schizophrenia using magnetic resonance imaging.

Methods: High-spatial resolution magnetic resonance images were used to measure the gray matter volume of the fusiform gyrus in 22 patients with first-episode schizophrenia (first hospitalization), 20 with first-episode affective psychosis (mainly manic), and 24 control subjects.

Results: Patients with first-episode schizophrenia had overall smaller relative volumes (absolute volume/intracranial contents) of fusiform gyrus gray matter compared with controls (9 and patients with affective psychosis (7 gyrus, patients with schizophrenia showed an 11 with controls and patients with affective psychosis. Right fusiform gyrus volume differed in patients with schizophrenia only compared with controls (8

Conclusions: Schizophrenia is associated with a bilateral reduction in fusiform gyrus gray matter volume that is evident at the time of first hospitalization and is different from the presentation of affective psychosis.


Lee CU, Shenton ME, Salisbury DF, Kasai K, Onitsuka T, Dickey CC, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW. Fusiform gyrus volume reduction in first-episode schizophrenia: A magnetic resonance imaging study. Arch Gen Psychiatry 2002;59:775-781.


NIH/NIMH 2K02 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799, NIH R01 RR11747, NIH P41 RR13218, VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009, Middleton Award, Welfide Foundation, Uehara Memorial Foundation

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