MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorderJ. S. Kwon, M. E. Shenton, Y. Hirayasu, D. F. Salisbury, I. A. Fischer, C. C. Dickey, D. Yurgelun-Todd, M. Tohen, R. Kikinis, F. A. Jolesz, R. W. McCarley
Am J Psychiatry
Volume 155, Number 4, Pages 509-515
Objective: A cavum between the septi pellucidi may reflect neurodevelopmental anomalies in midline structures of the brain. The authors examined cavum septi pellucidi in subjects with schizophrenia, affective disorder, and schizotypal personality disorder and in normal subjects.
Method: Thirty schizophrenic patients (15 chronic, 15 first-episode), 16 patients with affective disorder (first-episode), 21 patients with schizotypal personality disorder, and 46 normal subjects were evaluated with magnetic resonance imaging. Cavum septi pellucidi was assessed by counting the number of 1.5-mm slices containing cavum septi pellucidi.
Results: The presence or absence of cavum septi pellucidi did not differentiate among groups. However, the prevalence of abnormal cavum septi pellucidi (i.e., cavum septi pellucidi contained on four or more slices) was 30.4 for chronic, 25.0 affective disorder, 18.8 disorder, and 10.3 Nopoulos et al. criteria for rating cavum septi pellucidi, which omitted borderline cases with cavum septi pellucidi on three slices, the prevalence of abnormal cavum septi pellucidi increased to 35.0 for schizophrenia (40.0 for affective disorder, 27.3 and 13.0 difference in ratings between schizophrenic and normal subjects.
Conclusions: The results suggest that alterations in midline structures during the course of neurodevelopment may play a role in the pathogenesis of schizophrenia.