Diffusion Tensor Imaging And Its Application To Neuropsychiatric Disorders

M. Kubicki, C.-F. Westin, S. E. Maier, H. Mamata, M. Frumin, H. Ernst-Hirshefeld, R. Kikinis, F. A. Jolesz, R. W. McCarley, M. E. Shenton
Harvard Rev of Psychiatry
Volume 10, Pages 324-336

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Magnetic resonance diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue; it is particularly useful for evaluating white matter abnormalities. In this paper, we review research studies that have applied DTI for the purpose of understanding neuropsychiatric disorders. We begin with a discussion of the principles involved in DTI, followed by a historical overview of magnetic resonance diffusion-weighted imaging and DTI and a brief description of several different methods of image acquisition and quantitative analysis. We then review the application of this technique to clinical populations. We include all studies published in English from January 1996 through March 2002 on this topic, located by searching PubMed and Medline on the key words diffusion tensor imaging and MRI. Finally, we consider potential future uses of DTI, including ber tracking and surgical planning and follow-up.


Kubicki M, Westin CF, Maier SE, Mamata H, Frumin M, Ernst-Hirshefeld H, Kikinis R, Jolesz FA, McCarley RW, Shenton ME. Diffusion tensor imaging and its application to neuropsychiatric disorders, 2002.


NIH P41 RR13218, Young Investigator NARSAD (MF), Young Investigator NARSAD (MK), Grable Foundation, NIH RO1 MH50747, NIH/NIMH 2K02 MH01110, NIH R01 NS39335, NIH/NIMH 2RO1 MH40799, NIH R01 RR11747, NIH P41 RR13218, VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009, VA Psychiatry Research/Neuroscience Fellowship

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