Cingulate fasciculus integrity disruption in schizophrenia: A magnetic resonance diffusion tensor imaging study

M. Kubicki, C. F. Westin, P. G. Nestor, C. G. Wible, M. Frumin, S. Maier, R. Kikinis, F. A. Jolesz, R. W. McCarley, M. E. Shenton
Biol Psychiatry
Volume 54, Pages 1171-1180

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Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysi- ology of schizophrenia; however, the cingulum bundle (CB), the white matter tract furnishing both input and output to CG, and the most prominent white matter fiber tract in the limbic system, has not been evaluated in schizophrenia using the new technology of diffusion tensor imaging (DTI).

Methods: We used line scan DTI to evaluate diffusion in the CB in 16 male schizophrenia patients and 18 male control subjects, group-matched for age, parental socio- economic status, and handedness. We acquired 4-mm- thick coronal slices through the entire brain. Maps of fractional anisotropy (FA) were generated to quantify diffusion within the left and right CB on eight slices that included the central portion of the CB.

Results: Results showed group differences, bilaterally, in area and mean FA for CB, where patients showed smaller area and less anisotropy than controls. For patients, decreased left CB correlated significantly with attention and working memory measures as assessed by the Wis- consin Card Sorting Test.

Conclusions:These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormal- ities. Biol Psychiatry 2003;54:11711180 2003 Soci- ety of Biological Psychiatry


Kubicki M, Westin CF, Nestor PG, Wible CG, Frumin M, Maier S, Kikinis R, Jolesz FA, McCarley RW, Shenton ME. Cingulate fasciculus integrity disruption in schizophrenia: A magnetic resonance diffusion tensor imaging study. Biol Psychiatry 2003;54:1171-1180.


Young Investigator NARSAD(MK), Young Investigator NARSAD(MF), NIH RO1 MH50747, NIH/NIMH 2K02 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799, NIH RO1 NS39335, VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009, VA Psychiatry/Neuroscience Research Fellowship, National Center for Research Resources

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