Cavum septi pellucidi in first-episode schizophrenic and affective psychosis: An MRI study

K. Kasai, R. W. McCarley, D. F. Salisbury, T. Onitsuka, S. Demeo, D. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, M. E. Shenton
Schizophr Res
Volume 71, Pages 65-76

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A high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical symptoms, and with abnormalities in other limbic structures remains unclear, as does the question of whether a similar abnormality is present in affective psychosis. Seventy-four patients at their first hospitalization, 33 with schizophrenia and 41 with affective (mainly manic) psychosis, and 56 healthy control subjects underwent high-spatial-resolution magnetic resonance imaging (MRI). CSP on six slices or more on 0.9375-mm resampled coronal images was categorized as abnormal. The prevalence of abnormal CSP in both schizophrenic patients (26.1 (18.2 (8.2 associated with more severe thinking disturbance and smaller left parahippocampal gyrus gray matter volumes. While the relationships between CSP ratings and clinical symptoms did not significantly differ between the two psychosis groups as assessed by the comparison of regression slopes, the association with limbic volumes appeared to be specific to schizophrenic patients. These results suggest that psychosis associated with schizophrenia and affective disorder share, at least to some extent, neurodevelopmental abnormalities involving midline structures and associated psychopathological consequences. However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia. © 2004 Elsevier B.V. All rights reserved.


Kasai K, McCarley RW, Salisbury DF, Onitsuka T, Demeo S, Yurgelun-Todd D, Kikinis R, Jolesz FA, Shenton ME. Cavum septi pellucidi in first-episode schizophrenic and affective psychosis: An mri study. Schizophr Res 2004;71:65-76.


VA Merit Award, Middleton, NIH/NIMH 2R01 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799,

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