Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in schizophrenia: A longitudinal study of first-episode patients

K. Kasai, M. E. Shenton, D. F. Salisbury, Y. Hirayasu, T. Onitsuka, M. H. Spencer, D. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, R. W. McCarley
Arch Gen Psychiatry
Volume 60, Number 8, Pages 766-773
2003

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Abstract

Background: The Heschl gyrus and planum temporale have crucial roles in auditory perception and language processing. Our previous investigation using magnetic resonance imaging (MRI) indicated smaller gray matter volumes bilaterally in the Heschl gyrus and in left planum temporale in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis. We sought to determine whether there are progressive decreases in anatomically defined MRI gray matter volumes of the Heschl gyrus and planum temporale in patients with first-episode schizophrenia and also in patients with first-episode affective psychosis.

Methods: At a private psychiatric hospital, we conducted a prospective high spatial resolution MRI study that included initial scans of 28 patients at their first hospitalization (13 with schizophrenia and 15 with affective psychosis, 13 of whom had a manic psychosis) and 22 healthy control subjects. Follow-up scans occurred, on average, 1.5 years after the initial scan.

Results: Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left Heschl gyrus (6.9 patients with first-episode affective psychosis or control subjects.

Conclusions: These findings demonstrate a left-biased progressive volume reduction in the Heschl gyrus and planum temporale gray matter in patients with first-episode schizophrenia in contrast to patients with first-episode affective psychosis and control subjects. Schizophrenia but not affective psychosis seems to be characterized by a postonset progression of neocortical gray matter volume loss in the left superior temporal gyrus and thus may not be developmentally fixed.


Reference

Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Onitsuka T, Spencer MH, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW. Progressive decrease of left heschl gyrus and planum temporale gray matter volume in schizophrenia: A longitudinal study of first-episode patients. Arch Gen Psychiatry 2003;60(8):766-773.

Grants

VA Merit Award, Middleton, NIH/NIMH 2R01 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799,

Research area

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