Progressive decrease of left posterior superior temporal gyrus gray matter volume in patients with first-episode schizophrenia

K. Kasai, M. E. Shenton, D. F. Salisbury, Y. Hirayasu, C. U. Lee, A. Ciszewski, D. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, R. W. McCarley
Am J Psychiatry
Volume 160, Pages 156-164
2003

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Abstract

Objective: Smaller temporal lobe cortical gray matter volumes, including the left superior temporal gyrus, have been reported in magnetic resonance imaging (MRI) studies of patients with chronic schizophrenia and, more recently, in patients with first-episode schizophrenia. However, it remains unknown whether there are progressive decreases in temporal lobe cortical gray matter volumes in patients with first-episode schizophrenia and whether similarly progressive volume decreases are present in patients with affective psychosis.

Method: High-spatial-resolution MRI scans at initial hospitalization and 1.5 years later were obtained from 13 patients with first-episode schizophrenia, 15 patients with first-episode affective psychosis (mainly manic), and 14 healthy comparison subjects. MRI volumes were calculated for gray matter of superior temporal gyrus and for the amygdala-hippocampal complex.

Results:Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left superior temporal gyrus compared with patients with first-episode affective psychosis or healthy comparison subjects. This progressive decrease was more pronounced in the posterior portion of the left superior temporal gyrus (mean=9.6 (mean=8.4 present in other regions.

Conclusions: These findings demonstrate a progressive volume reduction of the left posterior superior temporal gyrus gray matter in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis.


Reference

Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Lee CU, Ciszewski A, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW. Progressive decrease of left posterior superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. Am J Psychiatry 2003;160:156-164.

Grants

VA Merit Award, Middleton, NIH/NIMH 2R01 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799, NIH R01 RR11747, Welfide Foundation, Uehara

Research area

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© 2013 Psychiatry Neuroimaging Laboratory | Last updated 04.15.2013