Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder

M. Frumin, P. Golland, R. Kikinis, Y. Hirayasu, D. F. Salisbury, J. Hennen, C. C. Dickey, M. Anderson, F. A. Jolesz, W. E. Grimson, R. W. McCarley, M. E. Shenton
Am J Psychiatry
Volume 159, Number 5, Pages 866-868
2002

Download full paper

Abstract

Objective: The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality.

Method: Corpus callosum area and shape were analyzed in 14 first-episode psychotic patients with schizophrenia, 19 first-episode psychotic patients with affective disorder, and 18 normal comparison subjects.

Results: No statistically significant corpus callosum area differences between groups were found, but there were differences in the structure's shape between the patients with schizophrenia and the comparison subjects. A correlation between width and angle of the corpus callosum was found in patients with affective disorder.

Conclusions: Corpus callosum shape abnormalities in first-episode psychotic patients with schizophrenia may reflect a midline neurodevelopmental abnormality.


Reference

Frumin M, Golland P, Kikinis R, Hirayasu Y, Salisbury DF, Hennen J, Dickey CC, Anderson M, Jolesz FA, Grimson WE, McCarley RW, Shenton ME. Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder. Am J Psychiatry 2002;159(5):866-868.

Grants

Ethel Dupont-Warren Fellowship Award, VA Psychiatry/Neuroscience Research Fellowship (MF), Stanley Foundation, NIH R01 RR11747, NIH P41 RR1321, NIH/NIMH 2K02 MH01110, NIH/NIMH 2RO1 MH40799, VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009, VA Schizophrenia Center Grant, Young Investigator NARSAD (MF), NSF IIS 9610249, Mitsubishi

Research areas

fe, shapeanalysis
© 2013 Psychiatry Neuroimaging Laboratory | Last updated 04.15.2013