On Diffusion Tensor Estimation

M. Niethammer, R. San Jose Estepar, S. Bouix, M. E. Shenton, C. F. Westin
International Conference of the Engineering in Medicine and Biology Society
Pages XX-XX
August, 2006

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In this paper we propose a formal formulation for the estimation of Diffusion Tensors in the space of symmetric positive semidefinite (PSD) tensors. Traditionally, diffusion tensor model estimation has been carried out imposing tensor symmetry without constraints for negative eigenvalues. When diffusion weighted data does not follow the diffusion model, due to noise or signal drop, negative eigenvalues may arise. An estimation method that accounts for the positive definiteness is desirable to respect the underlying principle of diffusion. This paper proposes such an estimation method and provides a theoretical interpretation of the result. A closed-form solution is derived that is the optimal data-fit in the matrix 2-norm sense, removing the need for optimization-based tensor estimation.


Niethammer M, Estepar RSJ, Bouix S, Shenton ME, Westin CF. On diffusion tensor estimation. In International Conference of the Engineering in Medicine and Biology Society. New York City, New York, USA: IEEE, 2006;XX-XX.


U54 EB005149, NIH RO1 MH50747, NIH/NIMH K05 70047, REAP, VA

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