Neocortical Gray Matter Volume in First-Episode Schizophrenia and First-Episode Affective Psychosis: A Cross-Sectional and Longitudinal MRI Study

M. Nakamura, D. F. Salisbury, Y. Hirayasu, S. Bouix, K. Pohl, T. Yoshida, M. Koo, M. Koo, R. McCarley
Biological Psychiatry
Volume 62, Number 7, Pages 773-783

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BACKGROUND: Overall neocortical gray matter (NCGM) volume has not been studied in first-episode schizophrenia (FESZ) at first hospitalization or longitudinally to evaluate progression, nor has it been compared with first-episode affective psychosis (FEAFF). METHODS: Expectation-maximization/atlas-based magnetic resonance imaging (MRI) tissue segmentation into gray matter, white matter (WM), or cerebrospinal fluid (CSF) at first hospitalization of 29 FESZ and 34 FEAFF, plus 36 matched healthy control subjects (HC), and, longitudinally approximately 1.5 years later, of 17 FESZ, 21 FEAFF, and 26 HC was done. Manual editing separated NCGM and its lobar parcellation, cerebral WM (CWM), lateral ventricles (LV), and sulcal CSF (SCSF). RESULTS: At first hospitalization, FESZ and FEAFF showed smaller NCGM volumes and larger SCSF and LV than HC. Longitudinally, FESZ showed NCGM volume reduction (-1.7 percent), localized to frontal (-2.4 percent) and temporal (-2.6 percent) regions, and enlargement of SCSF (7.2 percent) and LV (10.4 percent). Poorer outcome was associated with these LV and NCGM changes. FEAFF showed longitudinal NCGM volume increases (3.6 percent) associated with lithium or valproate administration but without clinical correlations and regional localization. CONCLUSIONS: Longitudinal NCGM volume reduction and CSF component enlargement in FESZ are compatible with post-onset progression. Longitudinal NCGM volume increase in FEAFF may reflect neurotrophic effects of mood stabilizers.


Nakamura M, Salisbury DF, Hirayasu Y, Bouix S, Pohl K, Yoshida T, Koo M, Koo M, McCarley R. Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: A cross-sectional and longitudinal mri study. Biological Psychiatry 2007;62(7):773-783.


REAP, VA Merit Award(MES) 2000-2008, VA Merit Award(RWM), Middleton Award, NIH/NIMH 2K02 MH01110, NIH RO1 MH50747, NIH/NIMH 2RO1 MH40799, NIH/NIMH RO1 MH58704, MIND Foundation, Young Investigator NARSAD (DFS), Welfide Foundation

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