Volume of cerebellar vermis in monozygotic twins discordant for combat exposure: lack of relationship to post-traumatic stress disorder

J. Levitt, Q. Chen, F. May, M. Gilbertson, M. E. Shenton, R. Pitman
Psychiatry Res
Volume 148, Number 2--3, Pages 143-149
2006

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Abstract

Several functional neuroimaging studies have implicated the cerebellar vermis in post-traumatic stress disorder (PTSD), but there have been no structural neuroimaging studies of this brain structure in PTSD. We utilized magnetic resonance imaging (MRI) with manual tracing to quantify the volumes of three divisions of the mid-sagittal vermis, and their total, within an identical, co-twin control design that employed Vietnam veterans discordant for combat exposure in Vietnam. Each structure's volume was significantly correlated between twins, indicating a partial familial determination: for anterior superior vermis, r=0.73; for posterior superior vermis, r=0.47; for inferior posterior vermis, r=0.51; and for total vermis, r=0.57. There were no significant differences between the PTSD and non-PTSD veterans for any vermis volume, and no significant main effects or interactions when their non-combat-exposed co-twins were added to the analyses. Thus, the results do not support the structural abnormality of cerebellar vermis in combat-related PTSD.


Reference

Levitt J, Chen Q, May F, Gilbertson M, Shenton ME, Pitman R. Volume of cerebellar vermis in monozygotic twins discordant for combat exposure: lack of relationship to post-traumatic stress disorder. Psychiatry Res 2006;148(2-3):143-149.

Grants

NIH/NIMH 2K02 MH01110, R01 MH54636

Research area

ptsd
© 2013 Psychiatry Neuroimaging Laboratory | Last updated 04.15.2013