A review of diffusion tensor imaging studies in schizophrenia

M. Kubicki, R. McCarley, C. F. Westin, H. Park, S. Maier, R. Kikinis, F. Jolesz, M. E. Shenton
J Psychiatr Res
Volume 41, Number 1--2, Pages 15-30

Download full paper


Both post-mortem and neuroimaging studies have contributed significantly to what we know about the brain and schizophrenia. MRI studies of volumetric reduction in several brain regions in schizophrenia have confirmed early speculations that the brain is disordered in schizophrenia. There is also a growing body of evidence suggesting that a disturbance in connectivity between different brain regions, rather than abnormalities within the separate regions themselves, are responsible for the clinical symptoms and cog- nitive dysfunctions observed in this disorder. Thus an interest in white matter fiber tracts, subserving anatomical connections between distant, as well as proximal, brain regions, is emerging. This interest coincides with the recent advent of diffusion tensor imaging (DTI), which makes it possible to evaluate the organization and coherence of white matter fiber tracts. This is an important advance as conventional MRI techniques are insensitive to fiber tract direction and organization, and have not consistently dem- onstrated white matter abnormalities. DTI may, therefore, provide important new information about neural circuitry, and it is increasingly being used in neuroimaging studies of psychopathological disorders. Of note, in the past five years 18 DTI studies in schizophrenia have been published, most describing white matter abnormalities. Questions still remain, however, regarding what we are measuring that is abnormal in this disease, and how measures obtained using one method correspond to those obtained using other methods? Below we review the basic principles involved in MR-DTI, followed by a review of the dfferent methods used to evaluate diffusion. Finally, we review MR-DTI findings in schizophrenia.


Kubicki M, McCarley R, Westin CF, Park H, Maier S, Kikinis R, Jolesz F, Shenton ME. A review of diffusion tensor imaging studies in schizophrenia, 2007.


NIH/NIMH R03 MH068464, NIH/NIMH 2K02 MH01110, NIH RO1 MH50747, NIH R01 NS39335, NIH/NIMH 2RO1 MH40799, NIH P41 RR13218, KOSEF, VA Merit Award(MES) 2000-2008, VA Merit Award(RWM) 1998-2009

Research areas

dti, chronic
© 2013 Psychiatry Neuroimaging Laboratory | Last updated 04.15.2013