Free-Form B-spline Deformation Model for Groupwise Registration

S. Balci, P. Golland, M. E. Shenton, W. Wells
Volume 4791, Pages 23-30
October, 2007

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In this work, we extend a previously demonstrated entropy based groupwise registration method to include a free-form deformation model based on B-splines. We provide an efficient implementation using stochastic gradient descents in a multi-resolution setting. We demonstrate the method in application to a set of 50 MRI brain scans and compare the results to a pairwise approach using segmentation labels to evaluate the quality of alignment. Our results indicate that increasing the complexity of the deformation model improves registration accuracy significantly, especially at cortical regions.


Balci S, Golland P, Shenton ME, Wells W. Free-form b-spline deformation model for groupwise registration. In miccai, volume 4791 of Lecture Notes in Computer Science. Heidelberg, Germany: Springer, 2007;23-30.


U54 EB005149, NIH P41 RR13218, U24 RR021382, R01-NS051826-01, NSF CAREER 0642971

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